Diagnostic gaps between depression, delirium: 4 study notes

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A study led by Cleveland Clinic found diagnostic agreement between primary services and consultation-liaison psychiatry for delirium was 88%, compared to 67% for strict depression diagnoses. 

The multisite study was published Dev. 5 in the Journal of Psychosomatic Research. Cleveland Clinic researchers examined how often hospitalized patients are diagnosed with depression or delirium, highlighting ongoing diagnostic challenges for nonpsychiatric clinicians. 

They conducted a chart review of almost 1,000 inpatient referrals made to consultation-liaison psychiatry services for suspected depression or delirium, comparing initial diagnoses from medical and surgical teams with final psychiatric evaluations.

Here are four things to know: 

  1. When depression was broadened to include adjustment disorders, agreement increased to 80%. 
  1. Among patients referred for depression who did not ultimately receive that diagnosis, nearly half were diagnosed with adjustment disorder. Other final diagnoses included anxiety disorders, delirium and neurocognitive issues. 
  1. For every 10-year increase in age, the odds of being misdiagnosed with depression decreased by up to 20%, suggesting expanded geriatric education may be contributing to improved accuracy. 
  1. Patients taking psychotropic medications were more than twice as likely to have delirium misdiagnosed as depression, suggesting medication lists may unintentionally influence clinical judgment. 
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