Sertraline was the most commonly prescribed antidepressant in the U.S. in 2022, according to June 7data from Definitive Healthcare, making up 13.1 percent of all prescribed mental health medications.
The 10 most commonly prescribed antidepressants and the percent of prescriptions dispensed in 2022:
1. Sertraline: 13.1 percent
2. Escitalopram: 10.8 percent
3. Trazodone: 9.7 percent
4. Fluoxetine: 8.8 percent
5. Bupropion: 7.9 percent
6. Duloxetine: 7.2 percent
7. Quetiapine: 5 percent
8. Citalopram: 4.9 percent
9. Venlafaxine: 4.8 percent
10. Aripiprazole: 3.7 percent