5 cities with the highest, lowest depression rates

Pearl City, Hawaii, is the city with the lowest depression rate, according to a Feb. 27 report on the "Happiest Cities in America" from WalletHub.

The report ranked 180 of the largest cities across the country on three key metrics: emotional and physical well-being, income and employment, and community and environment. 

Here are the cities with the highest and lowest depression rates:

Lowest depression rates

1. Pearl City, Hawaii
2. Honolulu
3. Fremont, Calif.
4. San Jose, Calif.
5. Irvine, Calif.

Highest depression rates

1. Lewiston, Maine
2. Huntington, W.Va.
3. Spokane, Wash.
4. Burlington, Vt.
5. Knoxville, Tenn.