UPMC develops xylazine treatment blueprint as exposure rises

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As xylazine’s presence in illicit opioid supply continues to climb, Pittsburgh, Penn.-based UPMC clinicians have developed new hospital protocols to improve care for patients exposed to the sedative. 

The protocols address complex withdrawal symptoms and severe skin wounds linked to xylazine, a drug increasingly turning up in toxicology screens, according to an April 17 news release from the system. 

The protocols were developed by a multidisciplinary team that included specialists in addiction medicine, emergency care, toxicology, psychiatry and surgery. 

The new guidelines, published April 15 in the Substance Use and Addiction Journal, provide clinicians with a step-by-step approach to implement from hospital admission through discharge. 

The initiative also includes educational resources for patients focused on wound care and harm reduction. 

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